Estimated mRNA vaccine effectiveness for prevention of infection, adjusted for study site, was 90% for full immunization and 80% for partial immunization. § In contrast, among fully immunized (≥14 days after second dose) persons, 0.04 infections per 1,000 person-days were reported, and among partially immunized (≥14 days after first dose and before second dose) persons, 0.19 infections per 1,000 person-days were reported. † Among unvaccinated participants, 1.38 SARS-CoV-2 infections were confirmed by reverse transcription–polymerase chain reaction (RT-PCR) per 1,000 person-days. Among 3,950 participants with no previous laboratory documentation of SARS-CoV-2 infection, 2,479 (62.8%) received both recommended mRNA doses and 477 (12.1%) received only one dose of mRNA vaccine. locations during December 14, 2020–March 13, 2021, CDC routinely tested for SARS-CoV-2 infections every week regardless of symptom status and at the onset of symptoms consistent with COVID-19–associated illness. Using prospective cohorts of health care personnel, first responders, and other essential and frontline workers* in eight U.S. Messenger RNA (mRNA) BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccines have been shown to be effective in preventing symptomatic COVID-19 in randomized placebo-controlled Phase III trials ( 1, 2) however, the benefits of these vaccines for preventing asymptomatic and symptomatic SARS-CoV-2 (the virus that causes COVID-19) infection, particularly when administered in real-world conditions, is less well understood. Fry, MD 1 Manjusha Gaglani, MBBS 9 ,11 ( View author affiliations) View suggested citation Arvay, PhD 1 Preeta Kutty, MD 1 Alicia M. Morrill, MS 7 Josephine Mak, MPH 1 Patrick Rivers, MPP 2 Katherine M. Herring, MPH 7 Gregory Joseph, MPH 1 Shawn Beitel, MSc 2 Tyler C. Wesley, MPH 7 Julie Mayo Lamberte, MSPH 1 Xiaoxiao Sun, PhD 2 Michael E. Edwards, MPH 7 Natasha Schaefer-Solle, PhD 8 Lauren Grant, MS 1 Katherine Ellingson, PhD 2 Holly C. Hegmann, MD 5 Elisha Stefanski 6 Laura J. Kuntz, PhD 3 Kayan Dunnigan, MPH 9 Marilyn J. Caban-Martinez, DO 8 Ashley Fowlkes, ScD 1 Karen Lutrick, PhD 2 Jennifer L.
Yoon, DO 5 Jennifer Meece, PhD 6 Lauren E.W.
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